Active CASP3 antibody
The Mouse Monoclonal anti-Active CASP3 antibody (Clone 5A2) (ABIN7250272) specifically detects Active CASP3 in IF, IHC (p) and WB.
The antibody is reactive with Human, Mouse and Rat samples.
Catalog No. ABIN7250272
$538.80
Plus shipping costs $50.00
Shipping to:
United States
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Quick Overview for Active CASP3 antibody (ABIN7250272)
Target
Active CASP3
Reactivity
Human, Mouse, Rat
Host
Mouse
Clonality
Monoclonal
Conjugate
Un-conjugated
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Clone
5A2
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Characteristics
- Monoclonal Antibody
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Purification
- Protein A purification
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Immunogen
- Recombinant Protein
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Isotype
- IgG
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anti-Active CASP3 (active) antibody
Reactivity: Human, Mouse, Rat IF, IHC (p), WB Host: Mouse Monoclonal 5A2 unconjugated
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Application Notes
- WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Active CASP3
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Background
- Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
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Molecular Weight
- 17 kDa
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UniProt
- P42574
Target
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