SMAD3 antibody
Quick Overview for SMAD3 antibody (ABIN7250293)
Target
See all SMAD3 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Characteristics
- Monoclonal Antibody
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Purification
- Protein A purification
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Immunogen
- Recombinant Protein
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Isotype
- IgG
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anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibody
SMAD3 Reactivity: Human WB, ELISA, IHC (p), PLA Host: Mouse Monoclonal 7F3 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (pSer423), (pSer425) antibodySMAD3 Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 1-230) antibodySMAD3 Reactivity: Human WB, ELISA, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibodySMAD3 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 2C12 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 1-110) antibodySMAD3 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 1C11 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 120-221) antibodySMAD3 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2C12 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 231-425) antibodySMAD3 Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (C-Term) antibodySMAD3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) (AA 186-215) antibodySMAD3 Reactivity: Human, Mouse WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB24758 unconjugated
anti-SMAD, Mothers Against DPP Homolog 3 (SMAD3) antibodyKO Validated SMAD3 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Monoclonal unconjugated
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Application Notes
- WB 1:1000-2000, IHC 1:100-200
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- SMAD3 (SMAD, Mothers Against DPP Homolog 3 (SMAD3))
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Alternative Name
- SMAD3
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Background
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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Molecular Weight
- 52 kDa
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UniProt
- P84022
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Pathways
- Cell Division Cycle, Chromatin Binding, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Autophagy
Target
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