beta Catenin antibody (pTyr654)
Quick Overview for beta Catenin antibody (pTyr654) (ABIN7250716)
Target
See all beta Catenin (CATNB) AntibodiesReactivity
Host
Clonality
Conjugate
Application
-
-
Binding Specificity
- pTyr654
-
Characteristics
- Phosphorylated antibody
-
Purification
- Affinity purification
-
Immunogen
- Synthesized peptide derived from human Catenin-beta around the phosphorylation site of Tyr654
-
Isotype
- IgG
-
-
anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reactivity: Human, Mouse, Rat WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 661-781) antibodyCATNB Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Pig, Rabbit, Sheep, Monkey, Hamster, Avian, Cat, Donkey, Goat, Guinea Pig, Horse WB, IF Host: Goat Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Zebrafish (Danio rerio) WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Hamster WB, IP, ICC, ICFC Host: Mouse Monoclonal EM-22 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Mouse Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) (AA 764-781) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
-
-
Application Notes
- WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- 1 mg/mL
-
Buffer
- PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
-
Preservative
- Sodium azide
-
Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Storage
- -20 °C
-
Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- beta Catenin (CATNB) (Catenin, beta (CATNB))
-
Alternative Name
- Catenin beta
-
Background
- Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
-
Molecular Weight
-
Observed_MW: 75 kDa
Calculated_MW: 85 kDa
-
UniProt
- P35222
-
Pathways
- Peptide Hormone Metabolism
Target
-
