COASY antibody

Catalog No. ABIN7255964

This Rabbit Polyclonal antibody specifically detects COASY in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for COASY antibody (ABIN7255964)

Target: COASY (CoA Synthase (COASY))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COASY antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COASY Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human COASY (NP_079509.5).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COASY

Target: COASY (CoA Synthase (COASY))

Alternative Name: COASY

Background: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.

Molecular Weight:

Observed_MW: 62 kDa

Calculated_MW: 62 kDa/65 kDa

Gene ID: 80347

UniProt: Q13057

Pathways: Ribonucleoside Biosynthetic Process