Importin 4 antibody

Catalog No. ABIN7258502

The Rabbit Polyclonal anti-Importin 4 antibody has been validated for IF. It is suitable to detect Importin 4 in samples from Human, Mouse and Rat.

Quick Overview for Importin 4 antibody (ABIN7258502)

Target: Importin 4 (IPO4)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 4 antibody is un-conjugated

Application: Immunofluorescence (IF)

Product Details anti-Importin 4 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human IPO4 (NP_078934.3).

Isotype: IgG

Application Details

Application Notes: IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Importin 4

Target: Importin 4 (IPO4)

Alternative Name: IPO4

Background: Importin-4is aproteinthat in humans is encoded by theIPO4gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Gene ID: 79711

UniProt: Q8TEX9

Pathways: Protein targeting to Nucleus