PARN antibody

Catalog No. ABIN7262849

This Rabbit Polyclonal antibody specifically detects PARN in WB and IF. It exhibits reactivity toward Human.

Quick Overview for PARN antibody (ABIN7262849)

Target: PARN (Poly A Specific Ribonuclease (PARN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PARN Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human PARN (NP_002573.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PARN

Target: PARN (Poly A Specific Ribonuclease (PARN))

Alternative Name: PARN

Background: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 73 kDa

Calculated_MW: 52 kDa/66 kDa/67 kDa/73 kDa

Gene ID: 5073

UniProt: O95453