PARN antibody (AA 1-639)

Catalog No. ABIN7163761

Product Details anti-PARN Antibody

Target: PARN (Poly A Specific Ribonuclease (PARN))

Binding Specificity: AA 1-639

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Poly(A)-specific ribonuclease PARN protein (1-639AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PARN

Target: PARN (Poly A Specific Ribonuclease (PARN))

Alternative Name: PARN (PARN Products)

Synonyms: parn-A antibody, xparn antibody, DAN antibody, RGD1565449 antibody, zgc:56067 antibody, 1200003I18Rik antibody, poly(A)-specific ribonuclease L homeolog antibody, poly(A)-specific ribonuclease antibody, poly(A)-specific ribonuclease (deadenylation nuclease) antibody, parn.L antibody, PARN antibody, Parn antibody, parn antibody

Background:

Background: 3\\\'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3\\\'-end poly(A) tail and the 5\\\'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3\\\'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Aliases: DAN antibody, Deadenylating nuclease antibody, Deadenylation nuclease antibody, PARN antibody, PARN_HUMAN antibody, Poly A specific ribonuclease antibody, Poly(A) specific ribonuclease antibody, Poly(A)-specific ribonuclease PARN antibody, Polyadenylate specific ribonuclease antibody, Polyadenylate-specific ribonuclease antibody

UniProt: O95453