KIR3DS1 antibody

Catalog No. ABIN7264954

This Rabbit Polyclonal antibody specifically detects KIR3DS1 in IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KIR3DS1 antibody (ABIN7264954)

Target: KIR3DS1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Short Cytoplasmic Tail, 1 (KIR3DS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR3DS1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-KIR3DS1 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human KIR3DS1 (NP_001077008.1).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KIR3DS1

Target: KIR3DS1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Short Cytoplasmic Tail, 1 (KIR3DS1))

Alternative Name: KIR3DS1

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID: 3813

UniProt: Q14943