CD2 antibody

Catalog No. ABIN7013989

The Rat Monoclonal anti-CD2 antibody has been validated for FACS, IP and Func. It is suitable to detect CD2 in samples from Mouse.

Quick Overview for CD2 antibody (ABIN7013989)

Target: CD2

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Clone: RM2-5

Product Details anti-CD2 Antibody

Purpose: Anti-Ms CD2 Purified Low Endotoxin

Specificity: The rat monoclonal antibody RM2-5 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells, also expressed by all thymocytes.

Purification: Purified by protein-G affinity chromatography.

Endotoxin Level: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: murine thymocytes

Isotype: IgG2b lambda

Application Details

Application Notes: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for CD2

Target: CD2

Alternative Name: CD2

Background: CD2 Molecule,CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.,LFA-2, Ly37, Ly-37

Gene ID: 12481

UniProt: P08920