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CNR2 antibody (Extracellular)

CNR2 Reactivity: Human WB, IF, IF (cc), LCI, IC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7043026
  • Target See all CNR2 Antibodies
    CNR2 (Cannabinoid Receptor 2 (CNR2))
    Binding Specificity
    • 16
    • 12
    • 10
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-24, Extracellular
    Reactivity
    • 55
    • 25
    • 21
    • 2
    • 1
    • 1
    Human
    Host
    • 57
    • 2
    • 1
    Rabbit
    Clonality
    • 58
    • 2
    Polyclonal
    Conjugate
    • 33
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CNR2 antibody is un-conjugated
    Application
    • 50
    • 32
    • 25
    • 21
    • 13
    • 13
    • 9
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI), Immunochromatography (IC)
    Purpose
    A Rabbit Polyclonal Antibody to Cannabinoid Receptor 2
    Specificity
    Extracellular, N-terminus
    Cross-Reactivity (Details)
    Not recommended to use with rat and mouse samples.
    Predicted Reactivity
    Canis,bovine - 10,14 amino acid residues identical
    Characteristics
    Anti-Human Cannabinoid Receptor 2 (extracellular) Antibody is directed against an extracellular epitope of the human CB2 receptor. Anti-Human Cannabinoid Receptor 2 (extracellular) Antibody (ABIN7043026, ABIN7044159 and ABIN7044160)) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize CB2 from human samples. The antibody is not recommended for use on rat and mouse samples.
    Purification
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)NGSKDGLDSNPMKD, corresponding to amino acid residues 11-24 of human CB2 receptor

    Isotype
    IgG
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    Discover our top product CNR2 Primary Antibody
  • Application Notes

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    Comment

    Negative Control: BLP-CR003

    Blocking Peptide: BLP-CR003

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Storage
    4 °C,-20 °C
    Storage Comment

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    CNR2 (Cannabinoid Receptor 2 (CNR2))
    Alternative Name
    CNR2 (CNR2 Products)
    Background
    CB2, CNR2,Cannabinoids have been used as pain relievers in Eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2 is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2 expression in brain is still much less characterized than that of CB1. Recently, it was demonstrated that CB2 is expressed in the brain and might have a role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2 was reported in several cancers such as prostate, glioma and acute myeloid leukemias.7-9 In human astrocytoma a direct relation between CB2 expression and tumor malignancy was demonstrated.8 Activation of CB2R in vivo by its agonist JWH-133, completely blocked cell growth.8 In C6 glioma, it was shown that activation of the CB2 by JWH-133 resulted in internalization of only the CB2 and not CB1 leading to apoptosis of the cells. This may well be a new approach for the treatment of glioma.

    Alternative names: Cannabinoid Receptor 2, CB2, CNR2
    Gene ID
    1269
    NCBI Accession
    NM_001841
    UniProt
    P34972
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