DLG1 antibody (L27 Domain, N-Term)

Catalog No. ABIN7887038

This Rabbit Polyclonal antibody specifically detects DLG1 in WB. It exhibits reactivity toward Human.

Quick Overview for DLG1 antibody (L27 Domain, N-Term) (ABIN7887038)

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DLG1 Antibody

Binding Specificity: AA 17-31, L27 Domain, N-Term

Purpose: A Rabbit Polyclonal Antibody to SAP-97

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Rat,mouse - identical

Characteristics: Anti-/DLG1 Antibody is directed against an epitope of human . Anti-/DLG1 Antibody (ABIN7043101, ABIN7045150 and ABIN7045151) can be used in western blot analysis. It has been designed to recognize from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235220)

Blocking Peptide: (ABIN7235220)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for DLG1

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Alternative Name: DLG1

Background:

Synonyms: Synapse-associated protein 97, Discs large homolog 1

Description: SAP-97 belongs to the MAGUK (membrane associated guanylate kinase) homologs along with PSD-95, PSD-93 and SAP102.Like other members, SAP-97 has three PDZ domains, one SH3 domain and an inactive GUK domain. Alternative splicing of SAP-97 gives to a number of different isoforms thereby complicating the understanding of its roles1.In the post-synaptic cell, SAP-97 is the only MAGUK to directly interact with the GluA1 AMPA receptor2. SAP-97 also directly interacts with NMDA receptors through the PDZ domain3,4.SAP-97 was shown to interact with KV1.45 and with KV4.2 where it directs the channel to spines in hippocampal neurons6. It can also interact with the channel in the heart7.Interactions with Kir channels have also been observed8,9.Thus, SAP-97 serves as a regulator of neuronal excitability and synaptic function. Roles for the protein in schizophrenia, Alzheimer's and Parkinson's disease and epilepsy have been found1.

Gene ID: 1739

NCBI Accession: NM_004087

UniProt: Q12959

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response