NPTXR antibody (Extracellular)

Catalog No. ABIN7043370

This anti-NPTXR antibody is a Rabbit Polyclonal antibody detecting NPTXR in WB, IHC, FACS and LCI. Suitable for Mouse.

Quick Overview for NPTXR antibody (Extracellular) (ABIN7043370)

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPTXR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Product Details anti-NPTXR Antibody

Binding Specificity: AA 162-176, Extracellular

Purpose: A Rabbit Polyclonal Antibody to NPTXR (extracellular)

Specificity: Extracellular, C-terminus

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Rat - identical, human - 14 out of 15 amino acid residues identical

Characteristics: Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (ABIN7043370, ABIN7044746 and ABIN7044747) is a highly specific antibody directed against an extracellular epitope of the mouse NPTXR. The antibody can be used in western blot and immunohistochemistry. It has been designed to recognize NPTXR from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1200

Application Dilutions Western blot wb: 1:400

Comment:

Negative Control: (ABIN7236082)

Blocking Peptide: (ABIN7236082)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for NPTXR

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Alternative Name: NPTXR

Background: NPR, NPTXR,Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer's disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.

Alternative names: NPR

Gene ID: 73340

NCBI Accession: NM_014293

UniProt: Q99J85