SSTR2 antibody (Intracellular)

Catalog No. ABIN7043764

This Rabbit Polyclonal antibody specifically detects SSTR2 in WB and IHC. It exhibits reactivity toward Rat.

Quick Overview for SSTR2 antibody (Intracellular) (ABIN7043764)

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SSTR2 Antibody

Binding Specificity: AA 339-359, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2

Specificity: Intracellular, C-terminus

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Mouse,human - identical

Characteristics: Anti-Somatostatin Receptor Type 2 Antibody (ABIN7043764, ABIN7045263 and ABIN7045264) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR2 from human, mouse, and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)ERSDSKQDKSRLNETTETQRT corresponding to residues 339-359 of rat SSTR2

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:400

Comment:

Negative Control: (ABIN7237235)

Blocking Peptide: (ABIN7237235)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Alternative Name: SSTR2

Background: SSTR2a, SS2R, Smstr2, SRIF1A,Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues1. In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner1,2.Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes1,2. Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner2.Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors3. Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors4.In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.

Alternative names: Somatostatin Receptor Type 2, SSTR2a, SS2R, Smstr2, SRIF1A

Gene ID: 54305

NCBI Accession: NM_001050

UniProt: P30680