UTS2R antibody (2nd Cytoplasmic Loop)

Catalog No. ABIN7886292

The Rabbit Polyclonal anti-UTS2R antibody (ABIN7886292) specifically detects UTS2R in WB and IHC. The antibody is reactive with Rat samples.

Quick Overview for UTS2R antibody (2nd Cytoplasmic Loop) (ABIN7886292)

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UTS2R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-UTS2R Antibody

Binding Specificity: 2nd Cytoplasmic Loop, AA 154-167

Purpose: A Rabbit Ployclonal Antibody to Urotensin II Receptor

Predicted Reactivity: Bovine - identical, human,canine - 13,14 amino acid residues identical

Characteristics: Anti-Urotensin II Receptor Antibody is directed against the 2nd cytoplasmic loop of the rat UTS2R. Anti-Urontenisn II Receptor Antibody (ABIN7043874 and ABIN7044242) can be used in western blot and immunohistochemical applications, and recognizes UTS2R in rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat URIIR

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Cited Application: IHC

Negative Control: (ABIN7237551)

Blocking Peptide: (ABIN7237551)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for UTS2R

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Alternative Name: UTS2R

Background:

Synonyms: Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14

Description: Urotensin II is a powerful vasoconstrictive substance. The human urotensin II receptor (UR-II-R) was originally isolated as an orphan receptor (GPR14) from neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues such as the CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5 Binding of urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that urotensin II is also expressed in various kinds of tumor cells such as adrenal tumors and neuroblastomas. In those cells, urotensin II was reported to stimulate cell growth.7-9

Gene ID: 57305

NCBI Accession: NM_018949

UniProt: P49684