Recombinant CD81 antibody

Catalog No. ABIN7072377

This anti-CD81 antibody is a Rabbit Chimeric antibody detecting CD81 in FACS, WB, ELISA, IP, IF, Func, IHC (p) and ICC. Suitable for Human, Sheep, Goat and Chimpanzee.

Quick Overview for Recombinant CD81 antibody (ABIN7072377)

Target: CD81

Antibody Type: Recombinant Antibody

Reactivity: Human, Sheep, Goat, Chimpanzee

Host: Rabbit

Clonality: Chimeric

Conjugate: This CD81 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: 1D6

Product Details anti-CD81 Antibody

Purpose: Anti-CD81 [1D6], Rabbit IgG, kappa

Specificity: This antibody is specific for human CD81, which is expressed on most tissues with the exception of red blood cells and platelets.

Cross-Reactivity: Chimpanzee, Goat, Sheep

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This antibody was produced by immunizing mice with 5A6-aggregated OCI-LY8 B cells.

Isotype: IgG kappa

Application Details

Application Notes: This antibody is a strong inducer of homotypic adhesion in hematolymphoid cells (Levy, 1998). This antibody also has an anti-proliferative effect, and is able to induce growth inhibition of B cell lines. Triggering of CD81 by this antibody induces a significant upregulation of the constituitive release of TNF-α by JY cells, an Eptsein-Barr virus-positive B lymphoblastoid cell line (Altomonte, 1995).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD81

Target: CD81

Alternative Name: CD81

Background: Tetraspanin-28, TAPA-1, Target of the Antiproliferative Antibody 1, Tspan-28

UniProt: P60033

Pathways: Inositol Metabolic Process, Hepatitis C