Recombinant CD37 antibody

Catalog No. ABIN7072379

The Rabbit Chimeric anti-CD37 antibody has been validated for FACS, IF, WB, IHC (p) and ICC. It is suitable to detect CD37 in samples from Human.

Quick Overview for Recombinant CD37 antibody (ABIN7072379)

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This CD37 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: MB-1

Product Details anti-CD37 Antibody

Purpose: Anti-CD37 [MB-1], Rabbit IgG, kappa

Specificity: This antibody is specific for human CD37, which is expressed on virtually all mature B lymphocytes, but not on pro-B or plasma cells. CD37 is highly expressed on all forms of B cell non-Hodgkin lymphoma, chronic lymphocyte leukemia, and other leukemias. CD37 does not appear to be expressed on T cells, thymocytes, granulocytes or platelets.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: BALB/c mice were immunized with lymph node cells from a patient with nodular poorly differentiated lymphocytic lymphoma. Immunophenotyping studies of these cells identified them as B cells expressing SIgG/lambda, as well as HLA-DR. Leu-12, and B1.

Isotype: IgG kappa

Application Details

Application Notes: This antibody recognizes human CD37, and has been used to identify and characterise the CD37 antigen in cell labelling, indirect immunofluorescence and IP analysis (Link, 1986). In particular, the use of this antibody to label malignant B cells indicates that expression of CD37 occurs relatively late in B cell maturation, as it is not expressed on "immature" B lineage lymphoid neoplasms.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD37

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Alternative Name: CD37

Background: Tetraspanin-26, Tspan-26, Leukocyte antigen CD37,

UniProt: P11049

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response