Recombinant EGFR (Nimotuzumab Biosimilar) antibody

Catalog No. ABIN7072381

This Human Monoclonal antibody specifically detects EGFR (Nimotuzumab Biosimilar) in FACS, BR and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant EGFR (Nimotuzumab Biosimilar) antibody (ABIN7072381)

Target: EGFR (Nimotuzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Human

Clonality: Monoclonal

Conjugate: This EGFR (Nimotuzumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Reagent (BR), Immunohistochemistry (IHC)

Clone: H-R3

Product Details anti-EGFR (Nimotuzumab Biosimilar) Antibody

Purpose: Anti-EGFR domain III [h-R3 (Nimotuzumab)], Human IgG1, kappa

Specificity: Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.

Isotype: IgG1 kappa

Application Details

Application Notes: This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for EGFR (Nimotuzumab Biosimilar)

Target: EGFR (Nimotuzumab Biosimilar)

Target Type: Biosimilar

Background: ERBB-D3, ERBB1, HER1, PIG61, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, epidermal growth factor

UniProt: P00533