Recombinant PD-1 antibody

Catalog No. ABIN7072412

The Rabbit Chimeric anti-PD-1 antibody has been validated for FACS, IHC (fro) and BR. It is suitable to detect PD-1 in samples from Mouse.

Quick Overview for Recombinant PD-1 antibody (ABIN7072412)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Chimeric

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Clone: RMP1-14

Product Details anti-PD-1 Antibody

Purpose: Anti-PD-1 [RMP1-14], Rabbit IgG, kappa

Specificity: This antibody binds to murine PD-1.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: The original rat hybridoma was generated by immunizing Sprague Dawley rats with mouse PD-1-transfectked BHK cells. A P3U1 myeloma was used as the fusion partner.

Isotype: IgG kappa

Application Details

Application Notes: Binding of the original rat IgG2a antibody to PD1 has been reported to prevent binding of both B7-H1-Ig (PD-L1-Ig) and B7-DC-Ig (PD-L2-Ig) fusion proteins to PD1.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PD-1

Background: CD279, PD1, PDCD1, RMPI-14, RMP1/14, Programmed Death Receptor 1, Programmed Death 1

Pathways: Cancer Immune Checkpoints