Recombinant CD276 antibody (Extracellular Domain)

Catalog No. ABIN7072435

This Rat Monoclonal antibody specifically detects CD276 in FACS and BR. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant CD276 antibody (Extracellular Domain) (ABIN7072435)

Target: CD276

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Clone: MJ18

Product Details anti-CD276 Antibody

Binding Specificity: AA 1-242, Extracellular Domain

Purpose: Anti-B7-H3 [MJ18], Rat IgG1, kappa

Specificity: This antibody binds to mouse B7-H3 and does not react with other B7-family molecules.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This antibody was generated by immunizing Sprague Dawley rats with B7-H3-Ig, consisting of the extracellular domain (aa1-242 of mouse B7-H3) linked to the Fc portion of mouse IgG2a, emulsified in CFA (Difco). The antibody was selected by its reactivity to mouse B7-H3-transfected cells, but not to parental cells by flow cytometry.

Isotype: IgG1 kappa

Application Details

Application Notes: This antibody has been used to detect murine B7-H3 by flow cytometry. It blocks B7-H3 signalling and can supress priming of Th2-responses and thereby the development of asthmatic responses in an ovalbumin-induced asthma model in BALB/c mice.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD276

Target: CD276

Alternative Name: B7-H3

Background: CD276, B7H3

UniProt: Q8VE98

Pathways: Cancer Immune Checkpoints