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Recombinant CD137 antibody

TNFRSF9 Reactivity: Mouse FACS, Act Host: Rat Monoclonal LOB12-3 unconjugated Recombinant Antibody
Catalog No. ABIN7072490
  • Target See all CD137 (TNFRSF9) Antibodies
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 101
    • 38
    • 26
    • 8
    • 4
    • 2
    • 1
    Mouse
    Host
    • 52
    • 37
    • 13
    • 12
    • 1
    Rat
    Clonality
    • 55
    • 55
    • 3
    Monoclonal
    Conjugate
    • 62
    • 12
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD137 antibody is un-conjugated
    Application
    • 66
    • 59
    • 56
    • 13
    • 12
    • 11
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Activation (Act)
    Purpose
    Anti-4-1BB [LOB12.3], Rat IgG2a, kappa
    Specificity
    This antibody binds to mouse 4-1BB (CD137).
    Characteristics

    Original Species of Ab: Rat

    Original Format of Ab: IgG1

    Purification
    Protein A affinity purified
    Immunogen
    This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
    Clone
    LOB12-3
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product TNFRSF9 Primary Antibody
  • Application Notes
    This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays.
    Comment

    This reformatted rat antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    Alternative Name
    4-1BB (TNFRSF9 Products)
    Background
    CD137, TNFRSF9, 41BB, 4-1BBL Ligand, Tumor necrosis factor superfamily member 9, TNF receptor superfamily member 9, LOB 12.3, LOB123, LOB12.3
    UniProt
    P20334
    Pathways
    Cancer Immune Checkpoints
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