Recombinant CD137 antibody
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- Target See all CD137 (TNFRSF9) Antibodies
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
- Antibody Type
- Recombinant Antibody
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This CD137 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Activation (Act)
- Purpose
- Anti-4-1BB [LOB12.3], Rat IgG2a, kappa
- Specificity
- This antibody binds to mouse 4-1BB (CD137).
- Characteristics
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Original Species of Ab: Rat
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
- Clone
- LOB12-3
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product TNFRSF9 Primary Antibody
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- Application Notes
- This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays.
- Comment
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This reformatted rat antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
- Alternative Name
- 4-1BB (TNFRSF9 Products)
- Background
- CD137, TNFRSF9, 41BB, 4-1BBL Ligand, Tumor necrosis factor superfamily member 9, TNF receptor superfamily member 9, LOB 12.3, LOB123, LOB12.3
- UniProt
- P20334
- Pathways
- Cancer Immune Checkpoints
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