Recombinant TNFSF15 antibody

Catalog No. ABIN7072491

This anti-TNFSF15 antibody is a Rabbit Chimeric antibody detecting TNFSF15 in IF, FACS and BP. Suitable for Mouse.

Quick Overview for Recombinant TNFSF15 antibody (ABIN7072491)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Chimeric

Conjugate: This TNFSF15 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Blocking Peptide (BP)

Clone: TAN2-2

Product Details anti-TNFSF15 Antibody

Purpose: Anti-TL1A [TAN2-2], Rabbit IgG, kappa

Specificity: This antibody is specific for TL1A, a member of the TNF ligand family. TL1A is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A has been shown to be expressed predominantly by CD4+CCR9+ lymphocytes. Its expression has been shown to be induced by TNF alpha, IL-1 alpha and IFN gamma.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising rats with a soluble recombinant TL1A (T77-L252):Fc protein.

Isotype: IgG kappa

Application Details

Application Notes: This antibody has been used in FACS analyses to reveal the role of TL1A in humoral immune responses and its mechanism of action in the development of collagen-induced arthritis (Wang et al, 2013), and in immunofluorescence confocal microscopy to demonstrate how chronic DR3 signaling could promote pathogenesis in inflammatory bowel disease (Taraban et al, 2011). The therapeutic potential of this antagonistic anti-TL1A antibody in countering the DR3-TL1A pathway in the inflammatory joint disease has been confirmed in both of the murine adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) models (Bull et al, 2008). In addition, this antibody has been demonstrated to prevent chronic colitis and attenuate established colitis by down-regulation of both T-helper 1 and T-helper 17 activation (Takedatsu et al, 2008).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Alternative Name: TL1A

Background: Tnfsf15, bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15), MGC129934, MGC129935, TL1, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, tumor necrosis factor (ligand) superfamily member 15, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor ligand 1B, Tumor necrosis factor ligand superfamily member 15, Vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A

UniProt: Q5UBV8

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy