Recombinant Interleukin 17a antibody

Catalog No. ABIN7072561

This Rabbit Chimeric antibody specifically detects Interleukin 17a in ELISA and BP. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant Interleukin 17a antibody (ABIN7072561)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Chimeric

Conjugate: This Interleukin 17a antibody is un-conjugated

Application: ELISA, Blocking Peptide (BP)

Clone: MM17F3

Product Details anti-Interleukin 17a Antibody

Purpose: Anti-IL-17A [MM17F3], Rabbit IgG, kappa

Specificity: This antibody is highly specific for murine IL-17A, in ELISA analysis, no cross-reactivity with IL-17B, IL-17C, IL-17D, IL-17E or IL-17F was observed.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising C57Bl/6 mice with IL-17A cross-linked to ovalbumin to generate a highly immunogenic complex.

Isotype: IgG kappa

Application Details

Application Notes: The specificity of this antibody has been confirmed in ELISA analysis (Uyttenhove et al, 2006). This antibody inhibits IL-17A-induced IL-6 production by a Cl1D fibroblastic cell line in vitro (Uyttenhove et al, 2006). This antibody has been shown to prevent experimental autoimmune encephalomyelitis (EAE) disease development in vivo (Uyttenhove et al, 2006), as well as protecting C57Bl/6 mice from myelin oligdendrocyte glycoprotein (MOG)-induced EAE (Uyttenhove et al, 2007). Additionally, administration of this antibody inhibits collagen-induced arthritis (CIA) in IFN-γ receptor knockout mice (Kelchtermans et al, 2009).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL-17A

Background: Interleukin-17A, IL17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8

UniProt: Q62386