Recombinant LAG3 antibody
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- Target See all LAG3 Antibodies
- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
- Antibody Type
- Recombinant Antibody
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This LAG3 antibody is un-conjugated
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Application
- Immunoprecipitation (IP), Flow Cytometry (FACS), Blocking Peptide (BP)
- Purpose
- Anti-LAG-3 [C9B7W], Rat IgG1, kappa
- Specificity
- This antibody is specific for an epitope in the D2 domain of murine LAG-3.
- Characteristics
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Original Species of Ab: Rat
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein.
- Clone
- C9B7W
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product LAG3 Primary Antibody
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anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibody
LAG3 Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB21775 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibodyLAG3 Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 4H6A3 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 Reactivity: Human WB, ELISA, IHC, FACS Host: Mouse Monoclonal 8B12E10 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibodyLAG3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 244-487) antibodyLAG3 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 209-451) antibodyLAG3 Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibodyLAG3 Reactivity: Human, Mouse WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) antibodyLAG3 Reactivity: Human ELISA, IHC (p), Coat Host: Mouse Monoclonal LAG3-3261 unconjugated
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- Application Notes
- This antibody has been used in flow cytometric analysis of splenocytes (Workman et al, 2005), T cell hybridomas expressing wild-type or chimeric CD4:murine LAG-3 (Workman et al, 2002) and CD4+ regulatory T cells (Chien et al, 2017). It has also been used in immunoprecipitation analysis of murine T hybridoma 3A9 cells transduced with murine LAG-3 (Li et al, 2004). This antibody blocks LAG-3 function in vitro, inhibiting antigen-induced IL-2 production in LAG-3-expressing T cell hybridomas, but does not block LAG-3:MHC class II interaction (Workman et al, 2002). Treatment with this antibody also blocks LAG-3 function in vivo, leading to accelerated homeostatic expansion of WT T cells (Workman et al, 2005). Administration of this LAG-3-blocking antibody, in combination with PD-L1 blockade, synergistically improves the survival of lymphodepleted myeloma-bearing mice (Jing et al, 2015).
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
- Alternative Name
- Lag3 (LAG3 Products)
- Background
- CD223, LAG3, Lymphocyte activation gene 3 protein
- UniProt
- Q61790
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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