Caspase 3 antibody (cleaved)

Catalog No. ABIN7073336

This Rabbit Polyclonal antibody specifically detects Caspase 3 in IHC and IF. It exhibits reactivity toward Human, Mouse and Rat and has been mentioned in 5+ publications.

Quick Overview for Caspase 3 antibody (cleaved) (ABIN7073336)

Target: Caspase 3 (CASP3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Caspase 3 Antibody

Binding Specificity: cleaved

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse caspase3

Application Details

Application Notes: IHC/IF (H,M,R) 1:500-1:1000/1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Caspase 3 antibody (ABIN7073336)

Chen, Jin, Wang, Liu, Luo, Tian, Cai, Meng, Bi, Wang, Xie, Yu, Li, Dong, Cai, Jia, Wei, Jia: "GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling." in: JCI insight, Vol. 5, Issue 3, (2021) (PubMed).

Chang, Shang, Yuan, Guo, Wang: "EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation." in: Cancer cell international, Vol. 21, Issue 1, pp. 531, (2021) (PubMed).

Wang, Zheng, Che, Han, Li, Wang, Liu, Shi, Sun: "Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway." in: Experimental and therapeutic medicine, Vol. 22, Issue 6, pp. 1400, (2021) (PubMed).

Elhadidy, Elmasry, Elsayed, El-Nablaway, Hamed, Elalfy, Rabei: "Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats." in: Heliyon, Vol. 7, Issue 10, pp. e08171, (2021) (PubMed).

Ma, Xu, Huang, Gao, Zhou, Li, Zhang: "Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation." in: Frontiers in physiology, Vol. 12, pp. 706359, (2021) (PubMed).

Target Details for Caspase 3

Target: Caspase 3 (CASP3)

Alternative Name: Caspase-3

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).

Gene ID: 12367

NCBI Accession: NP_001271338

UniProt: P70677

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation