GDF5 antibody

Catalog No. ABIN7074131

This Rabbit Polyclonal antibody specifically detects GDF5 in WB, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GDF5 antibody (ABIN7074131)

Target: GDF5 (Growth Differentiation Factor 5 (GDF5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GDF5 Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse GDF 5

Application Details

Application Notes: WB (H,M) 1:500-1:1000, IHC/IF (H,R) 1:200-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for GDF5

Target: GDF5 (Growth Differentiation Factor 5 (GDF5))

Alternative Name: GDF 5

Background: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .

Molecular Weight: 55 kDa

Gene ID: 14563

NCBI Accession: NP_032135

UniProt: P43027