SYTL2 antibody

Catalog No. ABIN7075797

The Rabbit Polyclonal anti-SYTL2 antibody is suitable to detect SYTL2 in samples from Human, Mouse and Rat. It has been validated for IHC and IF.

Quick Overview for SYTL2 antibody (ABIN7075797)

Target: SYTL2 (Synaptotagmin Like Protein 2 (SYTL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYTL2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SYTL2 Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse SYTL2/SLP2

Application Details

Application Notes: IHC/IF (H,M,R) 1:800-1:1600/1:600-1:1200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for SYTL2

Target: SYTL2 (Synaptotagmin Like Protein 2 (SYTL2))

Alternative Name: SYTL2/SLP2

Background: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Gene ID: 83671

NCBI Accession: NP_001035174

UniProt: Q99N50