ube3a antibody

Catalog No. ABIN7076104

This anti-ube3a antibody is a Rabbit Polyclonal antibody detecting ube3a in IHC and IF. Suitable for Mouse and Rat.

Quick Overview for ube3a antibody (ABIN7076104)

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ube3a antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ube3a Antibody

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse UBE3A

Application Details

Application Notes: IHC/IF (M,R) 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Alternative Name: UBE3A

Background: UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).

Gene ID: 22215

NCBI Accession: NP_035798

UniProt: O08759

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway