CD28 antibody (PE-Cy7)

Catalog No. ABIN7077085

Product Details anti-CD28 Antibody (PE-Cy7)

Target: CD28

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD28 antibody is conjugated to PE-Cy7

Application: Flow Cytometry (FACS)

Characteristics: The clone C-B281, a mouse monoclonal antibody selectively recognizes a 44 kDa type I cell surface glycoprotein known as CD28. It is expressed by all T cells and acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, B7-1 (CD80) and B7-2 (CD86), which are primarily expressed by the activated B cells as well as other antigen-presenting cells. CD28-CD28 ligands signaling induces TCR functional activation resulting T cell proliferation, production of higher levels of IL-2 and enhancing T cell cytotoxicity.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Recombinant human CD28 protein

Clone: C-B281

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD28

Target: CD28

Alternative Name: CD28 (CD28 Products)

Synonyms: Tp44 antibody, CD28RNA antibody, cd28 antibody, CD28 molecule antibody, CD28 antigen antibody, Cd28 molecule antibody, CD28 molecule L homeolog antibody, CD28 antibody, Cd28 antibody, cd28.L antibody

Background: The clone C-B281, a mouse monoclonal antibody selectively recognizes a 44 kDa type I cell surface glycoprotein known as CD28. It is expressed by all T cells and acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, B7-1 (CD80) and B7-2 (CD86), which are primarily expressed by the activated B cells as well as other antigen-presenting cells. CD28-CD28 ligands signaling induces TCR functional activation resulting T cell proliferation, production of higher levels of IL-2 and enhancing T cell cytotoxicity.

Gene ID: 940

UniProt: P10747

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response