CD45 antibody (iFluor™488)

Catalog No. ABIN7077251

Product Details anti-CD45 Antibody (iFluor™488)

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45 antibody is conjugated to iFluor™488

Application: Flow Cytometry (FACS)

Purpose: CD45 iFluor488 Antibody

Characteristics: The clone 2D1, a mouse monoclonal antibody, recognizes a hematopoietic cell surface glycoprotein antigen with a molecular weight of 180-220 kDa known as CD45. It is present on all human leukocytes including lymphocytes, monocytes, granulocytes, eosinophils, and basophils in peripheral blood. CD45 has a role in signal transduction, modifying signals from other surface molecules. 2D1 has been reported to react weakly with mature circulating erythrocytes and platelets. The antibody also recognizes the human leukocyte common antigen found on cells from spleen, lymph nodes, bone marrow cells and granulocytes.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Human PBMC

Clone: 2D1

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: CD45 (PTPRC Products)

Gene ID: 5788

NCBI Accession: NM_002838

UniProt: P08575

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling