CD8 alpha antibody (mFluor™510)

Catalog No. ABIN7077481

Product Details anti-CD8 alpha Antibody (mFluor™510)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is conjugated to mFluor™510

Application: Flow Cytometry (FACS)

Purpose: CD8a mFluor500 Antibody

Cross-Reactivity: Baboon, Chimpanzee, Cynomolgus, Green Monkey, Macaca nemestrina, Rhesus Monkey, Sooty mangabey (Cercocebus atys)

Characteristics: The clone SK1 specifically binds with a 32-34 kDa type I transmembrane glycoprotein of human cells commonly known as CD8a.  It is a member of immunoglobulin superfamily.  The CD8α forms either a homodimer (2 alpha chains) or a heterodimer with CD8β and is expressed on the surface of cytotoxic T cells, and sub-sets of NK cells, cortical thymocytes, and also on some dendritic cells. CD8 functions as a co-receptor for T cell receptor and specifically binds to class I MHC for antigen recognition and T cell activation. It has the cross-reactive binding affinity with the CD8 cell surface antigen expressing in several non-human primates, including Baboon, Chimpanzee, Cynomolgus and Rhesus.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Human peripheral blood T cells

Clone: SK1

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8a (CD8A Products)

Gene ID: 925

NCBI Accession: NM_001768

UniProt: P01732

Pathways: TCR Signaling