Myeloperoxidase antibody (FITC)

Catalog No. ABIN7077551

The Mouse Monoclonal anti-Myeloperoxidase antibody has been validated for FACS. It is suitable to detect Myeloperoxidase in samples from Human.

Quick Overview for Myeloperoxidase antibody (FITC) (ABIN7077551)

Target: Myeloperoxidase (MPO)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Myeloperoxidase antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: 8-9

Product Details anti-Myeloperoxidase Antibody (FITC)

Purpose: MPO FITC Antibody

Characteristics: The clone 8/9, a mouse monoclonal antibody selectively binds with myeloperoxidase (MPO), a glycoprotein present in the granules of myeloid cells. MPO is critical for an optimal oxygen-dependent microbicidal activity of myeloid cells. The MPO generally appears in the myeloblast stage of myeloid cell differentiation. It is the most common functional protein of myeloid cells and is involved in the process of inflammatory immune responses mediated by myeloid cells. The primary translation product of MPO undergoes glycosylation with the production of 89 kDa heme-free apopro-MPO form followed by incorporation of heme and conversion into the enzymatically active pro-MPO form. Subsequently, pro-MPO becomes targeted to azurophil granules where final processing occurs to produce mature dimeric MPO consisting of the 59-64 kDa MPO alpha-chain and the 14 kDa MPO beta-chain. MPO gene expression may serve as an additional marker for subclassification of acute leukemias and may be used to identify leukemic cells arrested at an early stage of the myeloid differentiation pathway.

Purification: Purified

Purity: >95 %

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for Myeloperoxidase

Target: Myeloperoxidase (MPO)

Alternative Name: MPO

Gene ID: 4353

UniProt: P05164

Pathways: Chromatin Binding