PD-1 antibody

Catalog No. ABIN7077584

Product Details anti-PD-1 Antibody

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: PD1 Unconjugated Antibody

Characteristics: The clone 6D5, a mouse monoclonal antibody selectively binds with a 50-55 kD cell surface protein commonly known as Programmed cell death 1 (PD-1) or CD279, a member of the immunoglobulin superfamily. PD-1 expression is mostly observed in activated T cells and B cells, and also in dendritic cells. PD-1 signals via binding its two ligands, PD-L1 and PD-L2. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T cell death. Blocking of PD-1 by its antibody restores T cells immunity against tumor and infectious agents. PD-1-blockade based immunotherapy is, therefore, highly clinically useful against various types of cancers and infectious diseases.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: PD1 transfected HEK293 cells

Clone: 6D5

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: PD1 (PDCD1 Products)

Gene ID: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints