Cullin 1 antibody (AA 701-776) (HRP)

Catalog No. ABIN705260

The Rabbit Polyclonal anti-Cullin 1 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect Cullin 1 in samples from Human.

Quick Overview for Cullin 1 antibody (AA 701-776) (HRP) (ABIN705260)

Target: Cullin 1 (CUL1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Cullin 1 Antibody (HRP)

Binding Specificity: AA 701-776

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cullin 1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Cullin 1

Target: Cullin 1 (CUL1)

Alternative Name: Cullin 1

Background:

Synonyms: Cullin-1, CUL 1, CUL1, Cullin1, MGC149834, MGC149835.

Background: Cullin 1 may be involved in the degradation of positive cell cycle regulators (for example G1 cyclins in yeast). Human cullin 1 forms a complex with Skp1 and the F box protein Skp2, which is thought to play a role in the ubiquitination of G1 regulatory proteins, as its homolog does in yeast.

Gene ID: 8454

Pathways: Cell Division Cycle, Hedgehog Signaling, Mitotic G1-G1/S Phases, Regulation of Cell Size