VAPB antibody (AA 51-150) (HRP)

Catalog No. ABIN705545

The Rabbit Polyclonal anti-VAPB antibody is suitable to detect VAPB in samples from Rat. It has been validated for WB, ELISA, IHC (p) and IHC (fro).

Quick Overview for VAPB antibody (AA 51-150) (HRP) (ABIN705545)

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAPB antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-VAPB Antibody (HRP)

Binding Specificity: AA 51-150

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VAPB

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for VAPB

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Alternative Name: VAPB

Background:

Synonyms: ALS 8, ALS8, D2Abb2e, UNQ484/PRO983, Vamp 33b, VAMP associated 33 kDa protein, VAMP associated protein B and C, VAMP associated protein B, VAMP associated protein B/C, VAMP associated protein C, VAMP B, VAMP B VAMP C, VAMP B/VAMP C, VAMP C, VAMP vesicle associated membrane protein associated protein B and C, Vamp33b, VAMPB, VAMPB/VAMPC, VAMPC, VAP 33b, VAP B, VAP B/VAP C, VAP C, VAP33b, VAPB/VAPC, VAPC antibody Vesicle associated membrane protein associated protein B and C, Vesicle associated membrane protein associated protein B/C, VAPB_HUMAN.

Background: VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980], also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.

Gene ID: 9217

Pathways: ER-Nucleus Signaling