XRN1 antibody (AA 1455-1706)

Catalog No. ABIN7090717

The Mouse Monoclonal anti-XRN1 antibody has been validated for WB. It is suitable to detect XRN1 in samples from Human.

Quick Overview for XRN1 antibody (AA 1455-1706) (ABIN7090717)

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This XRN1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: F12D4

Product Details anti-XRN1 Antibody

Binding Specificity: AA 1455-1706

Cross-Reactivity: Human

Predicted Reactivity: Mouse

Purification: Purified by Protein G.

Immunogen: Recombinant human XRN1 between1455-1706 amino acids.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for XRN1

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Alternative Name: XRN1

Background:

Synonyms: XRN1_HUMAN, Dhm2, mXRN1, SEP1, Strand-exchange protein 1 homolog, 5'-3' exoribonuclease 1.

Background: Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure.

Gene ID: 54464

UniProt: Q8IZH2