F2RL3 antibody (AA 101-200)

Catalog No. ABIN7090992

This Rabbit Polyclonal antibody specifically detects F2RL3 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for F2RL3 antibody (AA 101-200) (ABIN7090992)

Target: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F2RL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-F2RL3 Antibody

Binding Specificity: AA 101-200

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PAWR

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for F2RL3

Target: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Alternative Name: Par-4

Background:

Synonyms: 2310001G03Rik , PAR 4 , PAR-4 , Pawr , PAWR_HUMAN , PRKC Apoptosis WT1 Regulator , PRKC apoptosis WT1 regulator protein , Prostate apoptosis response 4 protein , Prostate apoptosis response protein 4 , prostate apoptosis response protein PAR-4 , Transcriptional repressor Par-4-like protein PAWR , Transcriptional repressor PAR4 , WT1 Interacting Protein

Background: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Gene ID: 5074

UniProt: Q96IZ0

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process