EPH Receptor B4 antibody

Catalog No. ABIN7091064

This Mouse Monoclonal antibody specifically detects EPH Receptor B4 in WB. It exhibits reactivity toward Human.

Quick Overview for EPH Receptor B4 antibody (ABIN7091064)

Target: EPH Receptor B4 (EPHB4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor B4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: B12M1

Product Details anti-EPH Receptor B4 Antibody

Predicted Reactivity: Human

Immunogen: Recombinant human EPHB4.

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Alternative Name: EPHB4

Background:

Synonyms: Eph receptor B4, EPHB4_HUMAN, Ephrin type-B receptor 4, Hepatoma Transmembrane Kinase, HTK, MYK1, TYRO11, Tyrosine-protein kinase receptor HTK, Tyrosine-protein kinase TYRO11.

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Gene ID: 2050

UniProt: P54760

Pathways: RTK Signaling