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LIM Domain Kinase 1 antibody (AA 459-508)

This Mouse Monoclonal antibody specifically detects LIM Domain Kinase 1 in WB. It exhibits reactivity toward Human.
Catalog No. ABIN7091334

Quick Overview for LIM Domain Kinase 1 antibody (AA 459-508) (ABIN7091334)

Target

See all LIM Domain Kinase 1 (LIMK1) Antibodies
LIM Domain Kinase 1 (LIMK1)

Reactivity

  • 105
  • 79
  • 73
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 102
  • 19
  • 3
Mouse

Clonality

  • 105
  • 19
Monoclonal

Conjugate

  • 58
  • 9
  • 8
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This LIM Domain Kinase 1 antibody is un-conjugated

Application

  • 89
  • 49
  • 26
  • 26
  • 26
  • 18
  • 16
  • 8
  • 7
  • 6
  • 6
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB)

Clone

L6K5
  • Binding Specificity

    • 23
    • 15
    • 15
    • 8
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 459-508

    Predicted Reactivity

    Human,Mouse

    Immunogen

    KLH conjugated synthetic peptide derived from human LIMK1
  • Application Notes

    WB 1:300-5000

    Restrictions

    For Research Use only
  • Concentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    LIM Domain Kinase 1 (LIMK1)

    Alternative Name

    LIMK1

    Background

    Synonyms: EC 2.7.11.1, LIM domain kinase 1, LIM motif-containing protein kinase, LIMK, LIMK-1, LIMK2, LIMK-2, LIM domain kinase 2, LIMK1_HUMAN.

    Background: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.

    Gene ID

    3984

    UniProt

    P53667

    Pathways

    Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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