MME antibody (AA 401-550)

Catalog No. ABIN7091386

The Mouse Monoclonal anti-MME antibody has been validated for WB and IHC (p). It is suitable to detect MME in samples from Human.

Quick Overview for MME antibody (AA 401-550) (ABIN7091386)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: B4S1

Product Details anti-MME Antibody

Binding Specificity: AA 401-550

Predicted Reactivity: Human

Immunogen: KLH conjugated synthetic peptide derived from human CD10

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: CD10

Background:

Synonyms: MME, NEP, NEP_HUMAN, Atriopeptidase, CALLA, CD 10, CD10, Common acute lymphocytic leukemia antigen, DKFZp686O16152, EC 3.4.24.11, Enkephalinase, EPN, gp100, Membrane metallo endopeptidase, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, Membrane metalloendopeptidase variant 1, Membrane metalloendopeptidase variant 2, MGC126681, MGC126707, Neprilysin, Neutral endopeptidase 24.11, Neutral endopeptidase, Neprilysin, Skin fibroblast elastase, SFE.

Background: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

Gene ID: 4311

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration