RCC1 antibody

Catalog No. ABIN7091643

This Mouse Monoclonal antibody specifically detects RCC1 in WB. It exhibits reactivity toward Human.

Quick Overview for RCC1 antibody (ABIN7091643)

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RCC1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: G14A2

Product Details anti-RCC1 Antibody

Predicted Reactivity: Human,Mouse

Immunogen: Recombinant human RCC1.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RCC1

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Alternative Name: RCC1

Background:

Synonyms: Cell cycle regulatory protein, CHC 1, CHC1, Chromosome condensation 1, Chromosome condensation protein 1, Guanine nucleotide releasing protein, HERC2, Ran GEF, RanGEF, RCC 1, RCC1 I, Regulator of chromosome condensation 1, Regulator of chromosome condensation, SHEP1, RCC1_HUMAN.

Background: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.

Gene ID: 1104

UniProt: P18754

Pathways: Chromatin Binding, Protein targeting to Nucleus