USP2 antibody (AA 1-258)

Catalog No. ABIN7091801

This anti-USP2 antibody is a Mouse Monoclonal antibody detecting USP2 in WB. Suitable for Human.

Quick Overview for USP2 antibody (AA 1-258) (ABIN7091801)

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1738CT331-50-87

Product Details anti-USP2 Antibody

Binding Specificity: AA 1-258

Cross-Reactivity: Green Monkey, Human

Purification: Purified by Protein G.

Immunogen: Recombinant human USP2 between 1-258 amino acids.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Alternative Name: USP2

Background:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 2, 3.4.19.12, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41

Background: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene ID: 9099

UniProt: O75604