CD86 antibody (AA 26-247)

Catalog No. ABIN7092885

This Rabbit Monoclonal antibody specifically detects CD86 in FACS and ELISA. It exhibits reactivity toward Human.

Quick Overview for CD86 antibody (AA 26-247) (ABIN7092885)

Target: CD86

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD86 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Clone: DM84

Product Details anti-CD86 Antibody

Binding Specificity: AA 26-247

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human B7-2 (Leu26-Pro247) (ABIN6961107) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1/5000-10000,Flow Cyt  1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for CD86

Target: CD86

Alternative Name: B7-2

Background: Synonyms:CD86, B7-2, B70, CD28LG2, LAB72, MGC34413
Description:This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Molecular Weight: 37.7kDa

Gene ID: 942

UniProt: P42081

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation