CD276 antibody (AA 29-245) (Biotin)

Catalog No. ABIN7093001

This anti-CD276 antibody is a Rabbit Monoclonal antibody detecting CD276 in ELISA and FACS. Suitable for Human.

Quick Overview for CD276 antibody (AA 29-245) (Biotin) (ABIN7093001)

Target: CD276

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD276 antibody is conjugated to Biotin

Application: ELISA, Flow Cytometry (FACS)

Clone: DM53

Product Details anti-CD276 Antibody (Biotin)

Binding Specificity: AA 29-245

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human  B7H3(Leu29-Pro245) (ABIN6961085) produced by using human HEK293 cells

Isotype: IgG

Application Details

Application Notes: ELISA 1/5000-10000,Flow Cyt  1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA,0.1 % Procline 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for CD276

Target: CD276

Alternative Name: B7-H3

Background: Synonyms:B7-H3, CD276, B7 homolog 3, B7H3
Description:The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 57 kDa

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints