OAS2 antibody

Catalog No. ABIN7111098

This anti-OAS2 antibody is a Rabbit Polyclonal antibody detecting OAS2 in WB, ELISA, IHC, IP and IF. Suitable for Human and Mouse.

Quick Overview for OAS2 antibody (ABIN7111098)

Target: OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-OAS2 Antibody

Purpose: OAS2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for OAS2

Target: OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))

Alternative Name: OAS2

Background:

Synonyms: 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2, 2-5A synthase 2)|p69 OAS / p71 OAS (p69OAS / p71OAS)|OAS2

Background: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

Molecular Weight: 66-71 kDa

Gene ID: 4939

UniProt: P29728

Pathways: Hepatitis C