ABHD2 antibody

Catalog No. ABIN7111166

The Rabbit Polyclonal anti-ABHD2 antibody has been validated for ELISA, WB and IHC. It is suitable to detect ABHD2 in samples from Human, Mouse and Rat.

Quick Overview for ABHD2 antibody (ABIN7111166)

Target: ABHD2 (Abhydrolase Domain Containing 2 (ABHD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABHD2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ABHD2 Antibody

Purpose: ABHD2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: abhydrolase domain containing 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ABHD2

Target: ABHD2 (Abhydrolase Domain Containing 2 (ABHD2))

Alternative Name: ABHD2

Background:

Synonyms: Monoacylglycerol lipase ABHD2|2-arachidonoylglycerol hydrolase|Abhydrolase domain-containing protein 2|Acetylesterase|Lung alpha/beta hydrolase 2|Progesterone-sensitive lipase|Protein PHPS1-2|ABHD2|LABH2

Background: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol(AG) from cell membrane(PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol(1AG) and 2-arachidonoylglycerol(2AG) to glycerol and arachidonic acid(AA)(PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation(PubMed:26989199). May also play a role in smooth muscle cells migration(By similarity).

Molecular Weight: 48 kDa

Gene ID: 11057

UniProt: P08910