ACPP antibody (AA 27-373)

Catalog No. ABIN7111188

This anti-ACPP antibody is a Mouse Monoclonal antibody detecting ACPP in WB, IHC and ELISA. Suitable for Human and Rat.

Quick Overview for ACPP antibody (AA 27-373) (ABIN7111188)

Target: ACPP (Acid Phosphatase, Prostate (ACPP))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACPP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 8D6

Product Details anti-ACPP Antibody

Binding Specificity: AA 27-373

Purpose: ACP3 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 27-373aa

Immunogen: acid phosphatase, prostate

Isotype: IgG2a

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ACPP

Target: ACPP (Acid Phosphatase, Prostate (ACPP))

Alternative Name: ACP3

Background:

Synonyms: Prostatic acid phosphatase (PAP)|5'-nucleotidase (5'-NT)|Acid phosphatase 3|Ecto-5'-nucleotidase|Protein tyrosine phosphatase ACP3|Thiamine monophosphatase (TMPase)|PAPf39|ACP3|ACPP

Background: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions( pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion(DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Molecular Weight: 48 kDa

Gene ID: 55

UniProt: P15309

Pathways: Synaptic Membrane, Ribonucleoside Biosynthetic Process