ATF6B antibody

Catalog No. ABIN7111248

This anti-ATF6B antibody is a Rabbit Polyclonal antibody detecting ATF6B in WB, ELISA, IHC, IF and IP. Suitable for Human, Mouse and Rat.

Quick Overview for ATF6B antibody (ABIN7111248)

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-ATF6B Antibody

Purpose: ATF6B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: activating transcription factor 6 beta

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:4000, IP:1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ATF6B

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Alternative Name: ATF6B

Background:

Synonyms: Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta)|Activating transcription factor 6 beta (ATF6-beta)|Protein G13|cAMP response element-binding protein-related protein (Creb-rp)|cAMP-responsive element-binding protein-like 1|Processed cyclic AMP-dependent transcription factor ATF-6 beta|ATF6B|CREBL1|G13

Background: The endoplasmic reticulum (ER)-transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR). The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms(60,80kd )(PMID: 11256944)

Molecular Weight: 110 kDa, 60 kDa, 80 kDa

Gene ID: 1388

UniProt: Q99941

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction