ARL2 antibody

Catalog No. ABIN7111380

This anti-ARL2 antibody is a Rabbit Polyclonal antibody detecting ARL2 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for ARL2 antibody (ABIN7111380)

Target: ARL2 (ADP-Ribosylation Factor-Like 2 (ARL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ARL2 Antibody

Purpose: ARL2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ADP-ribosylation factor-like 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ARL2

Target: ARL2 (ADP-Ribosylation Factor-Like 2 (ARL2))

Alternative Name: ARL2

Background:

Synonyms: ADP-ribosylation factor-like protein 2|ARL2

Background: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors(GEF) and GTPase-activating proteins(GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Molecular Weight: 21-25 kDa

Gene ID: 402

UniProt: P36404

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location