AFF4 antibody (AA 1-307)

Catalog No. ABIN7111407

This anti-AFF4 antibody is a Rabbit Polyclonal antibody detecting AFF4 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for AFF4 antibody (AA 1-307) (ABIN7111407)

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-AFF4 Antibody

Binding Specificity: AA 1-307

Purpose: AFF4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-307aa

Immunogen: AF4/FMR2 family, member 4

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for AFF4

Target: AFF4 (AF4/FMR2 Family, Member 4 (AFF4))

Alternative Name: AFF4

Background:

Synonyms: AF4/FMR2 family member 4|ALL1-fused gene from chromosome 5q31 protein (Protein AF-5q31)|Major CDK9 elongation factor-associated protein|AFF4|AF5Q31|MCEF

Background: Key component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

Molecular Weight: 150 kDa

Gene ID: 27125

UniProt: Q9UHB7