alpha 2 Macroglobulin antibody (AA 1100-1474)

Catalog No. ABIN7111503

This anti-alpha 2 Macroglobulin antibody is a Mouse Monoclonal antibody detecting alpha 2 Macroglobulin in WB, IHC and ELISA. Suitable for Human.

Quick Overview for alpha 2 Macroglobulin antibody (AA 1100-1474) (ABIN7111503)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 6D0

Product Details anti-alpha 2 Macroglobulin Antibody

Binding Specificity: AA 1100-1474

Purpose: A2M antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1100-1474aa

Immunogen: alpha-2-macroglobulin

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:1000, IF: 1:50-1:500, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2M

Background:

Synonyms: Alpha-2-macroglobulin (Alpha-2-M)|C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|A2M|CPAMD5

Background: Alpha-2-macroglobulin, also known as α2-macroglobulin(α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer's disease.

Molecular Weight: 185 kDa

Gene ID: 2

UniProt: P01023

Pathways: Lipid Metabolism